TB-500 is a synthetic peptide related to Thymosin β4, a naturally occurring actin-binding protein. It is studied in preclinical research for its role in cell migration and tissue remodeling, and it is a research-use-only compound — not approved for human use.
- Origin: corresponds to the active region of Thymosin β4 (a 43-amino-acid actin-binding protein).
- Studied for: actin regulation, cell migration, angiogenesis and tissue remodeling — in animal and in vitro models.
- Often paired with: BPC-157 in repair-focused research.
- Status: not FDA-approved; research use only; prohibited in competitive sport.
What is TB-500?
TB-500 is a synthetic version of the active region of Thymosin β4 (Tβ4), one of the body’s primary actin-regulating proteins. Actin is the protein that forms the internal “scaffolding” of cells, so molecules that influence it are of interest in research on how cells move and reorganize during repair.
| Class | Synthetic peptide (Thymosin β4 fragment) |
| Parent protein | Thymosin β4 (43 aa, actin-binding) |
| Research areas | Cell migration, angiogenesis, tissue remodeling |
| Lab form | Lyophilized (freeze-dried) powder |
| Status | Not approved for human use — research only |
What researchers study
Findings below come from animal and in vitro studies of TB-500 or its parent protein, not from established human use:
- Cell migration — how cells move into and reorganize an area during tissue repair.
- Angiogenesis — formation of new blood vessels in repair models.
- Tissue remodeling — cardiac, musculoskeletal, epithelial and endothelial models.
Proposed mechanisms
- Actin binding — regulates the G-actin/F-actin cycle that drives cell shape and movement.
- Angiogenic signaling — associated with new blood-vessel formation in models.
- Cytoskeletal reorganization — supports the structural changes cells undergo during remodeling.
TB-500 and BPC-157
TB-500 is frequently studied alongside BPC-157 because both appear in repair-focused research, though they act through different mechanisms. Some researchers investigate them together as the BPC-157 / TB-500 blend. For a side-by-side, see our BPC-157 vs TB-500 comparison.
Storage & handling
TB-500 is supplied as a lyophilized powder. Keep it cold and protected from light, reconstitute only when needed for research, and limit freeze–thaw cycles. See our guide on reconstituting lyophilized peptides.
Research status
TB-500 is not approved by the FDA or other regulators for human use; the available evidence is largely preclinical. It is also prohibited in competitive sport. Treat it strictly as a research compound.
Looking for research-grade TB-500?
Lab-tested, with third-party purity verification.